• Describe the historical evolution of platelet manufacturing, comparing manual whole blood component separation and apheresis collection in terms of process steps, product consistency, donor burden, and contribution to supply constraints.
• Analyze clinical and operational outcome data from centers implementing newer platelet manufacturing approaches and determine how these changes could be applied in their own practice settings to improve efficiency, safety, and platelet availability.
• Explain the core principles and key features of automated whole blood processing systems (for example, single-spin, integrated component extraction) and compare their potential advantages and limitations relative to traditional manual and apheresis-based methods when making or influencing local transfusion practice decisions.

Activity Disclosure

This activity is supported by Terumo BCT.

This activity underwent review in line with standards of editorial integrity and publication ethics. Potential conflicts of interest have been identified and resolved in accordance with John Wiley and Sons, Inc.’s Policy on Activity Disclosure and Conflict of Interest. The primary resolution method was review by an unconflicted expert. For information about the accreditation of this program, please contact [email protected].

Parts of this program’s content were developed using Claude Opus 4.7 (June 2026). All materials were reviewed and approved by the Wiley content strategist team and an external peer reviewer. No clinical material was created with the use of Claude or any other artificial intelligence.