ABO-Mismatched Platelet and Plasma Transfusion Practices and the Potential for Transfusion-Related Alpha-Gal Syndrome (TRAGS): The Biomedical Excellence for Safer Transfusion (BEST) Collaborative Study

Alpha-gal syndrome (AGS) is a tick-related meat allergy, and the molecule behind it closely resembles the blood Group B antigen. Recent case reports of severe allergic reactions in Group O patients given Group B plasma or platelets point to a possible new risk: transfusion-related alpha-gal syndrome (TRAGS). This CME activity is based on an international study in Transfusion by the BEST Collaborative. It looks at how often Group O patients receive Group B or AB plasma and platelets, and what this possible risk means for ABO-mismatched transfusion practice.

Target Audience

Healthcare Professionals 

Learning Objectives

  • Explore the frequency of group B and AB plasma and platelet transfusions to group O patients as it might apply to the potential for transfusion-related alpha-gal syndrome

Activity Disclosure

No commercial support has been accepted related to the development or publication of this activity.

This activity underwent peer review in line with the standards of editorial integrity and publication ethics. Conflicts of interest have been identified and resolved in accordance with John Wiley and Sons, Inc.’s Policy on Activity Disclosure and Conflict of Interest.

Course summary

Available credit: 
  • 1.00 AMA PRA Category 1 Credit(s)™
Course opens: 
09/10/2025
Course expires: 
09/09/2028
Cost:
$0.00

Article Authors

Dunbar NM, Kaufman RM, Bary KS, Bellairs GRM, Cohn CS, Delettre F, Ditcham S, Duarte GC, Ellison A, Fachini R, George CE, Humbrecht C, Louw V, Meier S, Morley S, Mwase M, Robitaille N, Rushford K, Sato T, Schafer R, Staves J, Takanashi M, Tiberghien P, Wendel S, Wood EM, Ziman A, and Murphy MF

CME Editor

 

Julie Katz Karp MD

Julie Katz Karp MD

Julie Katz Karp MD has nothing to disclose.

 

John Wiley & Sons, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

John Wiley and Sons, Inc. designates this journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity. For information on applicability and acceptance of continuing medical education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within 1 hour. To successfully earn credit, participants must complete the activity during the valid credit period, which is up to three years from initial publication. Additionally, up to 3 attempts and a score of 70% or better is needed to pass the post test and claim CC credit. [ACGME competency/CC category: Medical Knowledge].

Available Credit

  • 1.00 AMA PRA Category 1 Credit(s)™

Price

Cost:
$0.00
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