What is different about migraine in women? Although the diagnostic criteria for migraine are the same among genders, women often have more severe, prolonged attacks with a greater burden of accompanying symptoms. In addition to the increased attack severity and associated disability, migraine in women is often influenced by female sex hormones. The onset of puberty is associated with a higher incidence of migraine, hormonal changes during the menstrual cycle drive increased headache frequency during menses, pregnancy may be associated with changes in migraine frequency and phenotype, and migraine activity often increases again during perimenopause before decreasing in the post-menopausal period. A person’s sex also affects treatment of migraine, as menstrual migraine treatment may be approached differently than migraine outside of menses. Management of migraine in females is also often informed by the possibility of pregnancy. This virtual issue of Headache highlights recent research relevant to migraine in women, with a focus on papers published in the past 2 years.