This educational resource is intended to provide healthcare professionals with the tools to aid in the effective management of cancer cachexia, empowering them to provide the highest standard of care to their patients.
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Video Introduction
This animed video covers the topic of Early Recognition of Cancer cachexia: The Perception vs. Reality Gap
Learning Activities
This is the core of the hub: a set of activities designed to build on each other, covering the clinical questions that come up most often in practice. Work through them in whatever order suits you and pick up where you left off, and where CME credit is available, you'll see it noted on the activity itself.

Case Study with Professor Richard Dunne
Prof. Richard Dunne discusses the case of a patient with cancer cachexia with a focus on diagnosis, early intervention and management

Prof. Richard Dunne discusses the case of a patient with cancer cachexia, highlighting the challenges with treatment strategies and interventions.
Release Date: 09 October 2025

Advancing Cancer Cachexia Care: Evidence-Based Practices and Multidisciplinary Collaboration
Explore our on-demand webinar designed to elevate healthcare professionals' expertise in managing cancer cachexia through comprehensive care. In this session, Prof. Aminah Jatoi discusses the application of evidence-based guidelines and the integration of palliative care to enhance patient outcomes. Following that, Prof. Jeffrey Crawford delves into the critical roles of nutrition, exercise, and…
Available credit upon completion:
- 1.25 AMA PRA Category 1 Credit™

Early Recognition and Intervention in Cancer Cachexia: Pathophysiology, Diagnosis, and Management
In a recent webinar, Professors Aminah Jatoi, Jeffrey Crawford, and Rony Dev delved into the multifaceted nature of cancer cachexia, examining its definition, underlying pathophysiology, and profound impact on patients' quality of life. The session underscored the critical importance of early diagnosis and timely intervention, highlighting a multidisciplinary approach that includes nutritional su…
Supplementary Materials
The learning doesn't stop at the activities. Here you'll find infographics that make the key data easy to take in at a glance, coverage from the conferences shaping this field, and reports that go deeper on the evidence. Save them, revisit them, or share them with colleagues who'd find them useful.
Highlights of American Society of Clinical Oncology (ASCO) Annual Meeting 2025
These videos will provide valuable insights and updates on cancer cachexia research from ASCO 2025 Prof. Dunne presents key studies from the ASCO conference indicating that cancer cachexia worsens survival outcomes, particularly affecting older adults and being more prevalent in Black/African American patients, possibly due to social, environmental, and biological factors.
ASCO GI Highlights
In this video, Prof. Richard Dunne presents key highlights from the 2026 ASCO Gastrointestinal (GI) Cancers Symposium, focusing on cancer cachexia. The presentation covers recent research on the impact of muscle wasting during neoadjuvant chemotherapy, the benefits of dietician-led nutritional care post-pancreatic surgery, and emerging therapies like Ponsegromab targeting GDF-15.
Highlights of American Association for Cancer Research (AACR) Annual Meeting 2025
Release Date: 22 May 2025
Highlights of European Society for Medical Oncology (ESMO) Congress 2025
Prof. Crawford presents a pivotal study on the efficacy and safety of ponsegromab in patients with cancer-associated cachexia. He also highlights the RIVER-mPDAC study and the JMT203 study, both of which were presented at ESMO this year.
Annual Conference on Sarcopenia, Cachexia, and Wasting Disorder (SCWD) 2024 Highlights
Release Date: 19 March 2025
Annual Conference on Sarcopenia, Cachexia, and Wasting Disorder (SCWD) 2025 Highlights
Release Date: 19 December 2025

Cancer Cachexia: Importance of Early Recognition and Intervention
Cancer cachexia is a complex syndrome affecting many cancer patients, impacting their quality of life and prognosis. Early recognition and intervention are vital. This infographic provides an overview of its pathophysiology, highlights early recognition strategies, outlines diagnostic criteria, and offers management approaches. Discover essential insights to improve care for those affected by can…

Clinical Management of Cancer Cachexia: A Multimodal Treatment Approach
This infographic offers healthcare professionals essential strategies for managing cancer cachexia, focusing on symptom palliation and the importance of multidisciplinary care. It covers multimodal treatment components, including nutritional support, physical activity, psychological support, and pharmacological interventions, in line with current treatment guidelines. Additionally, it provides in…
Meet the Faculty
Meet our Editorial Panel featuring key opinion leaders in the field of cancer cachexia. This expert panel, in collaboration with the WILEY editorial team, has curated the independent educational modules where you can get resources on the latest advancements in research, treatment guidelines, and management of cancer cachexia.

Aminah Jatoi, M.D
Betty J. Foust, MD and Parents' Professor of Oncology, Mayo Clinic, Rochester, Minnesota
Aminah Jatoi, M.D. is Professor of Oncology at the Betty J. Foust, M.D. and Parents’ Professor of Oncology at Mayo Clinic in Minnesota, where she primarily cares for patients with gastrointestinal and gynecological malignancies. Her research focuses on supportive care issues in cancer patients. The author of 300+ publications, she seeks to mitigate side effects from the cancer treatment, anxiety related to the cancer and to cancer treatment, and distressing signs and symptoms related to the cancer itself with a special emphasis on such research in older patients with cancer. Her research has been funded by National Cancer Institute and various foundations. She also serves on the editorial boards for the Journal of Clinical Oncology; American Journal of Hospice and Palliative Medicine; Current Opinion in Supportive and Palliative Care; Journal of Cachexia, Sarcopenia and Muscle; Journal of Cancer Education, Journal of Geriatric Oncology, and the Mayo Clinic Proceedings. In addition to her clinical and research activities, Dr. Jatoi is active in education. She has been recognized with several teaching awards, including Teacher of the Year. She is the director and principal investigator on a Mayo Clinic junior faculty training program funded by the National Cancer Institute and provides mentorship to many residents, fellows and junior faculty.

Dr. Richard Dunne
Associate Professor of Medicine & Section Leader, GI Oncology, Wilmot Cancer Institute and The University of Rochester Medical Center
Dr. Richard Dunne is an Associate Professor of Medicine and is the Section Leader of GI Oncology at the Wilmot Cancer Institute and The University of Rochester Medical Center. His research is focused on furthering our understanding of the mechanisms and effects of Cancer Cachexia and the development of novel therapeutics in this space. His work is supported by the U.S. National Cancer Institute and Cancer Research UK. He is the study chair and PI for the U.S. Nationwide observational LOTUS trial, which seeks to develop a new classification system for Cancer Cachexia and update current definitions.

Dr. Rony Dev
Associate Professor, Department of Palliative Care and Rehabilitation Medicine, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas.
Dr. Rony Dev is an Associate Professor in the Department of Palliative Care and Rehabilitation Medicine, Division of Cancer Medicine, at the University of Texas MD Anderson Cancer Center, Houston, Texas. He is board certified in Internal Medicine and Palliative Care. Dr. Dev provides palliative care consultation regarding pain and symptom management for patients with cancer. He is the Director of the Nutrition Rehabilitation and Cachexia Clinic. His research interests include symptom management including the treatment of anorexia-cachexia syndrome, improving communication in family meetings for patients with cancer and their caregivers, and interventions to improve adaptive coping mechanisms for critically ill patients. He has published in numerous journals regarding screening for malnutrition in ambulatory supportive care clinics, treatments for anorexia and cancer cachexia, and the management of hormonal abnormalities including hypovitaminosis D in patients with cancer. He received the Young Investigator's Award, MASCC 2009, International Symposium, and is a member of the American Society of Clinical Oncology and American Academy of Hospice and Palliative Medicine. He is the section editor for Symptoms for PC-FACS for Journal of Pain and Symptom Management and an Editorial Board member for Annals of Palliative Medicine.

Professor Jeffrey Crawford
George Barth Geller Professor Emeritus for Research in Cancer, Department of Medicine, Duke University Medical Center
Professor Jeffrey Crawford MD is a graduate of Ohio Wesleyan University and Ohio State University School of Medicine. He completed his training in internal medicine and hematology oncology at Duke University. Over his career at Duke, Dr Crawford has served as clinical director of the thoracic oncology program, chief of the division of medical oncology, and associate director for clinical research for the Duke Cancer Institute. Dr Crawford has had a long term commitment to National Cancer Institute clinical trials, and has served in a number of leadership positions within Cancer and Leukemia Group B and the Alliance. He is currently a member of the executive committee and board of directors for the Alliance Foundation. Dr Crawford’s research has been in clinical trials in lung cancer with a focus on supportive care. He has published more than 250 articles. His expertise includes the role of hematopoietic growth factors for the management of chemotherapy induced myelosuppression, as well as the study of novel agents for cancer cachexia.
External Supplementary Resources
Sometimes the best next step sits outside this hub. We've gathered the published articles our faculty consider essential reading on this topic, along with links to the journals where the latest work in this field appears.
External Resources (95 links) — click to expand
- [18F]FDG-PET/CT imaging in assessing cancer-induced cachexia
- Cancer Cachexia Prevalence Is Underestimated in Medical Records of Patients in a Regional Tertiary Hospital
- A Cross-Sectional Study: Association Between Nutritional Quality and Cancer Cachexia, Anthropometric Measurements, and Psychological Symptoms
- A Phase Ib First-In-Patient Study Assessing the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Ponsegromab in Participants with Cancer and Cachexia
- A randomized controlled trial evaluating the effects of anamorelin in postoperative patients with upper gastrointestinal cancer: protocol for the CLEAR-UP study
- A randomized phase II feasibility trial of a multimodal intervention for the management of cachexia in lung and pancreatic cancer
- A Randomized Trial of Nutrition and Exercise Treatment in Patients With Pancreatic and Non-Small Cell Lung Cancer (NEXTAC-TWO)
- A Systematic Review and Meta-Analysis of the Clinical Use of Megestrol Acetate for Cancer-Related Anorexia/Cachexia
- A systematic review examining nutrition support interventions in patients with incurable cancer
- Addressing unmet needs for people with cancer cachexia: recommendations from a multistakeholder workshop
- Adult starvation and disease-related malnutrition: a proposal for etiology-based diagnosis in the clinical practice setting from the International Consensus Guideline Committee
- Advancements of investigational agents for cancer cachexia: what clinical progress have we seen in the last 5 years?
- Cancer Cachexia: ASCO Guideline Rapid Recommendation Update
- Assessing the impact of early palliative care intervention in patients with lung cancer, cachexia and weight loss
- Association between dietary fiber intake and cancer cachexia: mediation by inflammatory biomarkers
- Association Between Dietary Vitamin K Intake With Cancer Cachexia and Mortality: NHANES 1999–2018
- Bridging gaps in cancer cachexia Care: Current insights and future perspectives
- Bridging gaps in cancer cachexia Care: Current insights and future perspectives
- Cachexia and Dietetic Interventions in Patients With Esophagogastric Cancer: A Multicenter Cohort Study
- Cancer-associated cachexia
- Cancer-associated malnutrition, cachexia and sarcopenia: the skeleton in the hospital closet 40 years later
- Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia
- Cancer Cachexia: Beyond Weight Loss
- Cancer cachexia: exploring parallels with other paraneoplastic syndromes
- The barriers to interprofessional care for cancer cachexia among Japanese healthcare providers: A nationwide survey
- The influence of different muscle mass measurements on the diagnosis of cancer cachexia
- Cancer Cachexia: New Insights and Future Directions
- Cancer cachexia onset and survival outcomes in metastatic colorectal cancer: Comparative assessment of the asian working group for cachexia and the European palliative care research collaborative criteria, and utility of modified glasgow prognostic score
- Cancer therapy and cachexia
- Clinical impact of cancer cachexia on the outcome of patients with non-small cell lung cancer with PD-L1 tumor proportion scores of ≥50% receiving pembrolizumab monotherapy versus immune checkpoint inhibitor with chemotherapy
- Comparison of Orally Administered Cannabis Extract and Delta-9-Tetrahydrocannabinol in Treating Patients With Cancer-Related Anorexia-Cachexia Syndrome: A Multicenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial From the Cannabis-In-Cachexia-Study-Group
- Decreased appetite in cancer patients treated with immune checkpoint inhibitors (ICIs): The MOUSEION-012 systematic review and meta-analysis
- Definition and classification of cancer cachexia: an international consensus
- Diagnostic criteria for cancer cachexia: reduced food intake and inflammation predict weight loss and survival in an international, multi-cohort analysis
- Differentiating Sarcopenia and Cachexia Among Patients With Cancer
- Dose-dependent effect of megestrol acetate supplementation in cancer patients with anorexia–cachexia syndrome: A meta-analysis
- Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia: A North Central Cancer Treatment Group Study
- Early nutritional and inflammation assessment predicts prognosis in patients with cancer across tumor origin and metastatic status
- Early recognition of malnutrition and cachexia in the cancer patient: a position paper of a European School of Oncology Task Force
- Effect of a leucine-rich supplement in combination with nutrition and physical exercise in advanced cancer patients: A randomized controlled intervention trial
- Effect of anamorelin on body weight in patients with gastric cancer-associated cachexia: an observational study
- Effects of omega-3 supplementation on lean body mass in cancer patients: a systematic review and meta-analysis
- Effects of Peanut Butter Supplementation on Older Adults' Physical Function: A 6-Month Randomised Controlled Trial
- Efficacy and safety of anamorelin for cancer cachexia in patients with unresectable or recurrent gastric cancer: a multicentre, open-label, randomised controlled trial
- ESPEN guidelines on nutrition in cancer patients
- Evaluation of a Multidisciplinary Cachexia and Nutrition Support Service— The Patient and Carers Perspective
- Evidence-based Palliative Care Approaches to Non-pain Physical Symptom Management in Cancer Patients
- Exercise-based interventions for cancer cachexia: A systematic review of randomised and non-randomised controlled trials
- GDF-15 blockade: A multi-directional approach to potentiate cancer immunotherapy and alleviate cancer cachexia
- GDF15: from biomarker to target in cancer cachexia
- Growth Differentiation Factor 15 Serum Levels in Pancreatic Cancer
- Health care professionals’ experiences of dealing with cancer cachexia
- Holistic multimodal care for patients with cancer cachexia and their family caregivers
- Identification and management of cancer cachexia in patients: Assessment of healthcare providers' knowledge and practice gaps
- Inhibiting monoclonal antibody GDF-15 improves cancer cachexia symptoms
- Integrated nutritional care in cancer; about time?
- Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update
- LBA102 Efficacy and safety of ponsegromab in patients with cancer-associated cachexia: Results from the open-label extension of a randomized, placebo-controlled, phase II study
- Malnutrition and Cachexia in Inpatients With Acute Cardiac Conditions: A Scientific Statement From the American Heart Association
- Malnutrition risk screening in adult oncology outpatients: An ASPEN systematic review and clinical recommendations
- Malnutrition, sarcopenia and cachexia: exploring prevalence, overlap, and perceptions in older adults with cancer
- Management of Cancer Cachexia: ASCO Guideline
- Management of cancer cachexia towards optimizing care delivery and patient outcomes
- Metabolic Biomarkers for the Early Detection of Cancer Cachexia
- Metabolomics in cancer research and emerging applications in clinical oncology
- Multinational Association of Supportive Care in Cancer (MASCC) expert opinion/consensus guidance on the use of cannabinoids for gastrointestinal symptoms in patients with cancer
- Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours
- Nutrition rehabilitation programs and cachexia clinics for anorexia–cachexia syndrome in patients with cancer
- Nutritional Interventions to Improve Cachexia Outcomes in Cancer—A Systematic Review
- Nutritional strategies against skeletal muscle wasting in cancer-associated cachexia: the role of β-hydroxybutyrate and polyunsaturated fatty acids
- Omega-3 polyunsaterated fatty acids improve quality of life and survival, but not body weight in cancer cachexia: A systematic review and meta-analysis of controlled trials
- Overcoming barriers to timely recognition and treatment of cancer cachexia: Sharing Progress in Cancer Care Task Force Position Paper and Call to Action
- Pancreatic Damage in Ovarian Cancer–Associated Cachexia Is Driven by Activin A Signalling
- Physical function endpoints in cancer cachexia clinical trials: Systematic Review 1 of the cachexia endpoints series
- Ponsegromab for the Treatment of Cancer Cachexia
- Potential new treatment for cancer-related cachexia: Patients with cancer-related cachexia who were treated with ponsegromab had a significant increase in weight gain from the baseline in comparison with patients treated with a placebo
- Prevalence and Development of Cachexia Before and After Diagnosis of Non–small Cell Lung Cancer
- Prevalence of malnutrition in patients at first medical oncology visit: the PreMiO study
- Prospective study of anamorelin in pancreatic cancer cachexia: Clinical and translational insights into response heterogeneity
- Randomized Comparison of Megestrol Acetate Versus Dexamethasone Versus Fluoxymesterone for the Treatment of Cancer Anorexia/Cachexia
- Randomized Double-Blind Placebo-Controlled Study of Olanzapine for Chemotherapy-Related Anorexia in Patients With Locally Advanced or Metastatic Gastric, Hepatopancreaticobiliary, and Lung Cancer
- Real-world effectiveness of anamorelin in patients with unresectable and relapse pancreatic cancer: a prospective observational study
- Real-world safety and effectiveness of anamorelin for cancer cachexia: Interim analysis of post-marketing surveillance in Japan
- Reduced Muscle Loss in Patients With NSCLC Taking Fibrates: Findings From a Retrospective Observational Study
- Resistance Training Impact on Mobility, Muscle Strength and Lean Mass in Pancreatic Cancer Cachexia: A Randomized Controlled Trial
- Resistance training in cachectic pancreatic and lung cancer patients: randomised controlled trial
- The role of the nurse in meeting the educational needs for self-care in cachectic cancer patients and their family caregivers: A scoping review
- A multicenter, open-label, single-arm study of anamorelin (ONO-7643) in patients with cancer cachexia and low body mass index
- The effects of dietary advice on malnutrition in Cancer patients: a systematic review and meta-analysis
- The Multifaceted Role of Growth Differentiation Factor 15 (GDF15): A Narrative Review from Cancer Cachexia to Target Therapy
- The role of aerobic and resistance exercise for cancer cachexia management – A systematic scoping review
- The Role of New Agents and Supportive Care in a Multimodal Approach to Cancer Cachexia
- Weight loss in patients on osimertinib for metastatic EGFR-mutant non-small cell lung cancer
- Weight loss versus muscle loss: re-evaluating inclusion criteria for future cancer cachexia interventional trials
- Importance of Early Diagnosis and Integrated Care in Managing Cancer Cachexia

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