CME Credit Available

This educational resource is intended to provide healthcare professionals with the tools to aid in the effective management of cancer cachexia, empowering them to provide the highest standard of care to their patients.

Working in Collaboration with

This resource has been created in coordination with the American Cancer Society. Our editorial panel comprises of Key Opinion Leaders who have provided guidance in the development of all content on this site. This Knowledge Hub is supported by an educational grant from Pfizer.
Coming Soon

Webinar 17th November 2026: Where Science Is Going: New Therapeutics in Development in Cancer Cachexia

Three experts discuss the emerging cancer cachexia pipeline, how it compares with conventional appetite stimulants, and how to deliver multimodal care today. No agent is FDA-approved yet, so the pipeline is still investigational.

Video Introduction

This animed video covers the topic of Early Recognition of Cancer cachexia: The Perception vs. Reality Gap

Learning Modules

Module 1: Focus on Diagnosis

Cancer cachexia is often missed until it’s advanced. Learn how to define and diagnose it, tell it apart from sarcopenia and malnutrition, and spot the warning signs sooner.

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Module 1 Published 6 March 2025 Case Study

Cancer Cachexia: Diagnosis, Early Intervention, and Management

Prof. Richard Dunne discusses the case of a patient with cancer cachexia with a focus on diagnosis, early intervention and management

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Module 1 Published 19 March 2025 Conference Coverage

Annual Conference on Sarcopenia, Cachexia, and Wasting Disorder (SCWD) 2024 Highlights

Release Date: 19 March 2025

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Module 1 Published 1 April 2025 Infographic

Cancer Cachexia: Importance of Early Recognition and Intervention

Cancer cachexia is a complex syndrome affecting many cancer patients, impacting their quality of life and prognosis. Early recognition and intervention are vital. This infographic provides an overview of its pathophysiology, highlights early recognition strategies, outlines diagnostic criteria, and offers management approaches. Discover essential insights to improve care for those affected by can…

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Module 1 Published 22 May 2025 Conference Coverage

Highlights of American Association for Cancer Research (AACR)  Annual Meeting 2025

Release Date: 22 May 2025

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Module 1 60 min Published 9 June 2025 Webinar CME

(Part 1) Early Recognition and Intervention in Cancer Cachexia: Pathophysiology, Diagnosis, and Management

In a recent webinar, Professors Aminah Jatoi, Jeffrey Crawford, and Rony Dev delved into the multifaceted nature of cancer cachexia, examining its definition, underlying pathophysiology, and profound impact on patients' quality of life. The session underscored the critical importance of early diagnosis and timely intervention, highlighting a multidisciplinary approach that includes nutritional su…

Available credit upon completion:

  • 1.00 AMA PRA Category 1 Credit™
Available Now
Module 1 Published 18 June 2025 Conference Coverage

Highlights of American Society of Clinical Oncology (ASCO) Annual Meeting 2025

These videos will provide valuable insights and updates on cancer cachexia research from ASCO 2025 Prof. Dunne presents key studies from the ASCO conference indicating that cancer cachexia worsens survival outcomes, particularly affecting older adults and being more prevalent in Black/African American patients, possibly due to social, environmental, and biological factors.

Module 2: Treatment and Management of Cancer Cachexia

Effective cachexia care combines several approaches. Explore the evidence for nutrition, exercise, palliative care and drug therapies, and see how multidisciplinary teams put guidelines into practice.

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Module 2 Published 3 September 2025 Infographic

Clinical Management of Cancer Cachexia: A Multimodal Treatment Approach

This infographic offers healthcare professionals essential strategies for managing cancer cachexia, focusing on symptom palliation and the importance of multidisciplinary care. It covers multimodal treatment components, including nutritional support, physical activity, psychological support, and pharmacological interventions, in line with current treatment guidelines. Additionally, it provides in…

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Module 2 Published 8 October 2025 Case Study

Cancer Cachexia: Diagnosis, Early Intervention, and Management

Prof. Richard Dunne discusses the case of a patient with cancer cachexia, highlighting the challenges with treatment strategies and interventions.

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Module 2 Published 25 November 2025 Conference Coverage

Highlights of European Society for Medical Oncology (ESMO) Congress 2025

Prof. Crawford presents a pivotal study on the efficacy and safety of ponsegromab in patients with cancer-associated cachexia. He also highlights the RIVER-mPDAC study and the JMT203 study, both of which were presented at ESMO this year.

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Module 2 77 min Published 8 December 2025 Webinar CME

(Part 2) Advancing Cancer Cachexia Care: Evidence-Based Practices and Multidisciplinary Collaboration

Explore our on-demand webinar designed to elevate healthcare professionals' expertise in managing cancer cachexia through comprehensive care. In this session, Prof. Aminah Jatoi discusses the application of evidence-based guidelines and the integration of palliative care to enhance patient outcomes. Following that, Prof. Jeffrey Crawford delves into the critical roles of nutrition, exercise, and…

Available credit upon completion:

  • 1.25 AMA PRA Category 1 Credit™
Available Now
Module 2 Published 20 December 2025 Conference Coverage

Annual Conference on Sarcopenia, Cachexia, and Wasting Disorder (SCWD) 2025 Highlights

Release Date: 19 December 2025

Available Now
Module 2 Published 27 January 2026 Conference Coverage

ASCO GI Highlights

In this video, Prof. Richard Dunne presents key highlights from the 2026 ASCO Gastrointestinal (GI) Cancers Symposium, focusing on cancer cachexia. The presentation covers recent research on the impact of muscle wasting during neoadjuvant chemotherapy, the benefits of dietician-led nutritional care post-pancreatic surgery, and emerging therapies like Ponsegromab targeting GDF-15.

Module 3: Cancer Cachexia in Clinical Trials

New therapies are moving through clinical trials. Find out which agents are being tested, which endpoints matter, and how early recognition helps identify the right patients to take part.

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Module 3 3.30 min Published 8 September 2026 Video Infographic

Early Recognition of Cancer Cachexia: The Perception vs. Reality Gap

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Module 3 16 min Published 6 October 2026 KOL Video Commentary

Cancer Cachexia: Recognizing the Right Patient

Dr. Rony Dev (Department of Palliative Medicine, The University of Texas MD Anderson Cancer Center) explains how to recognize cancer cachexia in everyday oncology practice: what sets it apart from sarcopenia and malnutrition, why it can be missed in patients with normal or high BMI, and which assessments help identify it early. He also covers the dietitian's role, protein targets, and the case for multimodal, team-based care. Earlier recognition may mean more options for patients, including clinical trials of emerging therapies.

Meet the Faculty

Aminah Jatoi, M.D

Aminah Jatoi, M.D

Betty J. Foust, MD and Parents' Professor of Oncology, Mayo Clinic, Rochester, Minnesota

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Aminah Jatoi, M.D. is Professor of Oncology at the Betty J. Foust, M.D. and Parents’ Professor of Oncology at Mayo Clinic in Minnesota, where she primarily cares for patients with gastrointestinal and gynecological malignancies. Her research focuses on supportive care issues in cancer patients. The author of 300+ publications, she seeks to mitigate side effects from the cancer treatment, anxiety related to the cancer and to cancer treatment, and distressing signs and symptoms related to the cancer itself with a special emphasis on such research in older patients with cancer. Her research has been funded by National Cancer Institute and various foundations. She also serves on the editorial boards for the Journal of Clinical Oncology; American Journal of Hospice and Palliative Medicine; Current Opinion in Supportive and Palliative Care; Journal of Cachexia, Sarcopenia and Muscle; Journal of Cancer Education, Journal of Geriatric Oncology, and the Mayo Clinic Proceedings. In addition to her clinical and research activities, Dr. Jatoi is active in education. She has been recognized with several teaching awards, including Teacher of the Year. She is the director and principal investigator on a Mayo Clinic junior faculty training program funded by the National Cancer Institute and provides mentorship to many residents, fellows and junior faculty.

Dr. Richard Dunne

Dr. Richard Dunne

Associate Professor of Medicine & Section Leader, GI Oncology, Wilmot Cancer Institute and The University of Rochester Medical Center

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Dr. Richard Dunne is an Associate Professor of Medicine and is the Section Leader of GI Oncology at the Wilmot Cancer Institute and The University of Rochester Medical Center. His research is focused on furthering our understanding of the mechanisms and effects of Cancer Cachexia and the development of novel therapeutics in this space. His work is supported by the U.S. National Cancer Institute and Cancer Research UK. He is the study chair and PI for the U.S. Nationwide observational LOTUS trial, which seeks to develop a new classification system for Cancer Cachexia and update current definitions.

Dr.
Rony Dev

Dr. Rony Dev

Associate Professor, Department of Palliative Care and Rehabilitation Medicine, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas.

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Dr. Rony Dev is an Associate Professor in the Department of Palliative Care and Rehabilitation Medicine, Division of Cancer Medicine, at the University of Texas MD Anderson Cancer Center, Houston, Texas. He is board certified in Internal Medicine and Palliative Care. Dr. Dev provides palliative care consultation regarding pain and symptom management for patients with cancer. He is the Director of the Nutrition Rehabilitation and Cachexia Clinic. His research interests include symptom management including the treatment of anorexia-cachexia syndrome, improving communication in family meetings for patients with cancer and their caregivers, and interventions to improve adaptive coping mechanisms for critically ill patients. He has published in numerous journals regarding screening for malnutrition in ambulatory supportive care clinics, treatments for anorexia and cancer cachexia, and the management of hormonal abnormalities including hypovitaminosis D in patients with cancer. He received the Young Investigator's Award, MASCC 2009, International Symposium, and is a member of the American Society of Clinical Oncology and American Academy of Hospice and Palliative Medicine. He is the section editor for Symptoms for PC-FACS for Journal of Pain and Symptom Management and an Editorial Board member for Annals of Palliative Medicine.

Professor Jeffrey Crawford

Professor Jeffrey Crawford

George Barth Geller Professor Emeritus for Research in Cancer, Department of Medicine, Duke University Medical Center

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Professor Jeffrey Crawford MD is a graduate of Ohio Wesleyan University and Ohio State University School of Medicine. He completed his training in internal medicine and hematology oncology at Duke University. Over his career at Duke, Dr Crawford has served as clinical director of the thoracic oncology program, chief of the division of medical oncology, and associate director for clinical research for the Duke Cancer Institute. Dr Crawford has had a long term commitment to National Cancer Institute clinical trials, and has served in a number of leadership positions within Cancer and Leukemia Group B and the Alliance. He is currently a member of the executive committee and board of directors for the Alliance Foundation. Dr Crawford’s research has been in clinical trials in lung cancer with a focus on supportive care. He has published more than 250 articles. His expertise includes the role of hematopoietic growth factors for the management of chemotherapy induced myelosuppression, as well as the study of novel agents for cancer cachexia.

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