This educational resource is intended to provide healthcare professionals with the tools to aid in the effective management of Chronic Lymphocytic Leukemia (CLL), empowering them to provide the highest standard of care to their patients. Stay informed with our video series, including expert commentaries and practical webinars designed to enhance patient care and outcomes. Join us as we dive into cutting-edge research and emerging therapies aimed at tackling chronic lymphocytic leukemia.
Working in Collaboration with

Learning Activities
This is the core of the hub: a set of activities designed to build on each other, covering the clinical questions that come up most often in practice. Work through them in whatever order suits you and pick up where you left off, and where CME/CE credit is available, you'll see it noted on the activity itself.

Diagnostic Markers in Clinical Practice
Dr. Othman Al-Sawaf presented a case study on chronic lymphocytic leukemia, discussing the diagnostic workup, staging, and treatment options for a 65-year-old patient with advanced disease and low-risk CLL.

Navigating CLL Treatment: Approved Therapies and Overcoming Resistance
Dr. Romain Guieze presents a case study on managing chronic lymphocytic leukemia (CLL) with a focus on treatment options, resistance mechanisms, and genetic testing for a 72-year-old patient with a history of uncontrolled hypertension and multiple relapses.

Critical Role of Diagnostic Markers in Differentiating CLL from Other Hematological Malignancies
The objectives of this presentation by Dr. Delgado is to discuss the specific diagnostic markers for CLL and how we use this markers for patient certification.

Advanced Therapeutic Strategies and Resistance Mechanisms in CLL
Dr. Shankara Paneesha discussed the evolving treatment landscape for relapsed CLL, focusing on BTK resistance, new treatment options including cellular therapy, and the importance of patient-specific factors in treatment decisions.

Applying Diagnostic Markers in Clinical Practice and Incorporating Updated Guidelines into Treatment Plans for CLL
As a healthcare professional, you can enhance your decision making as you learn from leading experts in Chronic Lymphocytic Leukemia (CLL). Join our expert editorial panel as they offer a curated collection of patient case studies and key take-home messages on Chronic Lymphocytic Leukemia (CLL). Gain valuable perspectives on the latest advancements, challenges, and best practices in the diagnosis and management of CLL. Watch now to advance your practice and improve the lives of patients with CLL.
Supplementary Materials
The learning doesn't stop at the activities. Here you'll find infographics that make the key data easy to take in at a glance, coverage from the conferences shaping this field, and reports that go deeper on the evidence. Save them, revisit them, or share them with colleagues who'd find them useful.
ASH 2024 Conference Coverage
Video highlights from the 2024 ASH Conference featuring Dr. Kostas Stamatopoulos and Dr. Shankara Paneesha.

Enhancing Patient Outcomes in Chronic Lymphocytic Leukaemia
Insights on staging, prognostic biomarkers, and emerging treatments.

Recent Advances in Chronic Lymphocytic Leukemia Treatment
Key Insights from the American Society of Hematology 2024 Conference
Meet the Faculty
Meet our Editorial Panel featuring key opinion leaders in the field of Chronic Lymphocytic Leukemia (CLL). This expert panel, in collaboration with the WILEY editorial team, has curated the independent educational modules where you can get resources on the latest advancements in research, treatment guidelines, and management of CLL.

Dr. Tarec Christoffer El-Galaly
Professor, Aarhus University Consultant Hematologist, Aarhus University Hospital Chair, Danish Lymphoma Group and The Nordic Lymphoma Epidemiology Group
Tarec Christoffer El-Galaly is a consultant hematologist and professor at Aarhus University Hospital and Aarhus University. His main clinical and research area is lymphoid malignancies with a focus on outcomes research and epidemiology. He has published >150 papers and is involved in many national and international activities related to research in lymphoma and clinical guidelines. He is chair of the Danish Lymphoma Group and The Nordic Lymphoma Epidemiology Group.

Dr. Kostas Stamatopoulos
Research Director, Institute of Applied Biosciences at CERTH, Thessaloniki, Greece Visiting Professor, Karolinska Institute, Stockholm, Sweden
Kostas Stamatopoulos is a specialist in Hematology, Research Director at the Institute of Applied Biosciences at CERTH, the Center for Research and Technology Hellas, Thessaloniki, Greece. He also holds the position of Visiting Professor at the Karolinska Institute, Stockholm, Sweden. Dr Stamatopoulos is the Scientific Coordinator of GRECRIN, the Greek Clinical Infrastructure Network; national representative in the EU Cancer Mission; member of the Research and European Affairs Committes of the European Hematology association; Board member of ERIC, the European Research Initiative on chronic lymphocytic leukemia; Steering Committee member of the Scientific Working Group on Precision Hematology of the European Hematology Association. Between 2018-2021 he has served as Coordinator of the Hellenic Precision Medicine in Oncology. His research interests include: precision medicine in cancer; immunobiology of lymphoid malignancies with a particular focus on CLL; and, patient empowerment in care.

Dr. Julio Delgado
Head, Oncoimmunotherapy Unit, Hospital Clínic, Barcelona (HCB) Consultant Haematologist, Hospital Clínic, Barcelona (HCB) Researcher, IDIBAPS Biomedical Research Institute Associate Professor, University of Barcelona
Dr. Julio Delgado is the Head of the Oncoimmunotherapy Unit and consultant haematologist at Hospital Clínic, Barcelona (HCB), researcher at IDIBAPS Biomedical Research Institute, and associate professor at the University of Barcelona. He has been involved in the clinical development of ARI-0001 (varnimcabtagene autoleucel), the first 100% academic CART-cell product ever approved in an EU member state. He is a founding member of the Spanish Group for chronic lymphocytic leukaemia (CLL) and runs most CLL and CART-cell clinical trials at HCB. He is a core member of the EMA’s Scientific Advisory Group for Oncology, and advisor to the Spanish Medicines Agency and the Catalan Pharmacotherapy Committee. He is a member of HCB’s Advanced Therapies Committee and vice-president of the Institution’s Review Board/Ethics Committee. He is a past member of the EHA’s Education Committee and current member of the EHA’s European Affairs Committee. He is also the EHA’s representative at EMA’s health-care professionals working party (HCPWP). He has co-authored over 200 peer-reviewed papers.

Dr. Shankara Paneesha, MD FRCP FRCPath
Consultant Haematologist Honorary Associate Clinical Professor, University of Birmingham University Hospitals Birmingham NHS Foundation
Dr Shankara Paneesha graduated from Mysore University, India, in 1993, and obtained a postgraduate qualification in General Medicine from Bombay University, India, in 1996. He completed specialist training in haematology at the West Midlands Deanery following initial training at the Royal Free and the Royal Marsden Hospitals in London and was appointed as Consultant Haematologist at the Heart of England NHS Foundation Trust in March 2007. Dr Paneesha is currently involved in many trials in haemato-oncology, either as Principal Investigator or as Co-Investigator. Dr Paneesha is the Haematology MDT lead from 2012 and the current Ordinary Trustee for the British Society for Haematology, Deputy Medical Director - of Tertiary Services at UHB, Birmingham and Honorary Associate Clinical Professor, at the University of Birmingham.

Dr. Othman Al-Sawaf
Haematologist and Medical Oncologist, University Hospital Cologne, Cologne, Germany Principal Investigator, German CLL Study Group (GCLLSG)
Othman Al-Sawaf is a haematologist and medical oncologist at the University Hospital Cologne, Cologne, Germany, and principal investigator at the German CLL Study Group (GCLLSG). He studied medicine at the University of Aachen, Germany, and joined the Department I of Internal Medicine I of Professor Michael Hallek at the University Hospital of Cologne in 2016. Following his postdoctoral studies at the Francis Crick Institute and UCL Cancer Institute in London, he became group leader of the Integrated Cancer Research Laboratory at the CECAD Research Centre in Cologne in 2024. His clinical work focusses on the treatment of lymphoid and myeloid malignancies with particular focus on CLL and lymphoma. In addition to his clinical trial work that covers national and international phase I to III trials, he is interested in the principles of cancer evolution & metabolism. His research laboratory focusses on computational approaches for the discovery and development of new treatment strategies in clinical oncology.

Dr. Elias Campo, MD, PhD
Professor of Pathology and Senior Consultant, Hematopathology, Hospital Clinic of Barcelona, University of Barcelona Director, Institute for Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona
Elias Campo. MD, PhD, is Professor of Pathology and Senior Consultant of Hematopathology at the Hospital Clinic of Barcelona, University of Barcelona, and Director of the Institute for Biomedical Research August Pi i Sunyer (IDIBAPS) of Barcelona. His research focuses on the characterization of the pathology of lymphoid neoplasms and the understanding of the molecular and genetic mechanisms underlying the pathogenesis of these tumors. In the last years his work has concentrated in elucidating the genomic/epigenomic alterations in chronic lymphocytic leukemia, mantle cell lymphoma and other aggressive lymphomas and their impact in understanding the biology of these diseases and clinical management of the patients. He has been co-Director of the Spanish ICGC-CLL genome project and was elected member of the Royal Academy of Medicine of Catalonia, Spain, in 2012, member of the USA National Academy of Medicine in 2018, and Doctor Honoris Causa by the University of Toulouse III - Paul Sabatier, Toulouse, France (2024), among others.

Dr. Romain Guieze
Professor of Hematology, CHU Clermont-Ferrand, University Clermont Auvergne, France
Romain Guieze is Professor at the department of clinical hematology and cell therapy at University Hospital of Clermont-Ferrand (France). He has been trained in Clermont-Ferrand and Lille University Hospitals (medical school, residency), Institut Gustave Roussy, Paris (master degree) and Dana-Farber Cancer Institute, Boston (post-doc). He co-chairs the committee in charge of chronic lymphocytic leukemia (CLL) in the LYSA group. His research studies focus on CLL. He is developing clinical trials in the frontline CLL setting (STAIR, NCT04963946) and for patients with Richter transformation (BLINART, NCT03931642, Nat Commun 2024; GLORIFY, EUCT 2022-501554-11-00). A longstanding theme of his studies has been how to take into account the molecular features of leukemia cells to improve the management of patients. He contributed to investigate the factors driving resistance to cytotoxic agent (Blood 2015) or novel agents (Cancer Cell 2019) and to the transformation processes (Nat Med 2023).

Dr. Martin Šimkovič, Ph.D
Lead, Chronic Lymphocytic Leukemia (CLL) treatment group, IV. Internal Hematology Clinic, University Hospital Hradec Králové
Dr. Martin Šimkovič, Ph.D., leads the Chronic Lymphocytic Leukemia (CLL) treatment group at the IV. Internal Hematology Clinic, University Hospital Hradec Králové. His dissertation focused on CLL, and since 2017, he has been an active board member of the Czech Group for the Treatment of Chronic Lymphocytic Leukemia (ČSCLL). Dr. Šimkovič's research primarily explores advanced therapies for relapsed/refractory CLL, CLL epidemiology, and supportive treatment strategies. He has contributed to over 90 publications, garnering over 1,500 citations and achieving an H-index of 16 (Web of Science). As a co-investigator on numerous grants from the Czech Ministry of Health, he regularly presents his findings at prestigious international congresses such as ASH, EHA, and IWCLL. His clinical expertise extends to principal and co-investigator roles in studies focusing on CLL, non-Hodgkin lymphomas, Waldenström's macroglobulinemia, and immune thrombocytopenia.
External Supplementary Resources
Sometimes the best next step sits outside this hub. We've gathered the published articles our faculty consider essential reading on this topic, along with links to the journals where the latest work in this field appears.
External Resources (33 links) — click to expand
- Assessment of the Diagnostic and Prognostic Values of CD200 and CD43 in CLL and Leukemic Phase of NHL
- BCL2i-Based Therapies and Emerging Resistance in Chronic Lymphocytic Leukemia
- CAR-T Cell Therapy in CLL
- CAT rs1001179 Single Nucleotide Polymorphism Identifies an Aggressive Clinical Behavior in Chronic Lymphocytic Leukemia
- Characteristics and Outcomes of Patients with Double Refractory (DR) or Double Exposed (DE) CLL
- Chronic Lymphocytic Leukemia: 2025 Update on the Epidemiology, Pathogenesis, Diagnosis, and Therapy
- Consensus Recommendations from the 2024 Lymphoma Research Foundation Workshop on Treatment Selection and Sequencing in CLL or SLL
- Diagnostic next generation sequencing to detect MYD88 L265P in lymphoplasmacytic lymphoma compared to ddPCR
- Efficacy and challenges involving combination therapies in CLL
- Epigenetic features support the diagnosis of B-cell prolymphocytic leukemia and identify 2 clinicobiological subtypes
- Evaluation of the Findings of Peripheral Blood Smear, Bone Marrow Aspiration and Biopsy, Iron Storage, and Immunophenotype in Patients with Chronic Lymphocytic Leukemia
- Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia
- Improving Treatment Options for Patients with Double Refractory CLL
- Inflammatory Markers Significantly Increased in Patients Treated with Obinotuzumab for Lymphoproliferative Diseases
- Insights into genetic aberrations and signalling pathway interactions in chronic lymphocytic leukemia: from pathogenesis to treatment strategies
- JNK1 inhibitors target distal B cell receptor signaling and overcome BTK-inhibitor resistance in CLL
- Laboratories Can Reliably Detect Clinically Relevant Variants in the TP53 Gene below 10 % Allelic Frequency: A Multicenter Study of ERIC, the European Research Initiative on CLL
- Management strategies for patients with chronic lymphocytic leukaemia harbouring complex karyotype
- Molecular Composition and Kinetics of B Cells During Ibrutinib Treatment in Patients with Chronic Lymphocytic Leukemia
- Nx-2127 and Nx-5948, Two Clinical Stage Cereblon-Recruiting BTK Degraders, Facilitate T Cell Functionality in Chronic Lymphocytic Leukemia
- PD-1 Expression Identifies Proliferating Chronic Lymphocytic Leukemia Cells and Informs Response and Resistance to BTK Inhibitor Therapy
- Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia
- Precision Medicine in CLL: Treatment Based on Molecular Profiles
- Prognostic factors in chronic lymphocytic leukaemia – the old, the new and the future
- Real-world characteristics, treatment patterns, and outcomes of patients with 2 or more LOTs for CLL/SLL in the United States
- Single-cell analysis of a bi-clonal chronic lymphocytic leukemia reveals two clones with distinct gene expression pattern
- TP53 Gain-of-Function Mutants Display Unique Transcriptional Profiles in Chronic Lymphocytic Leukemia
- Treatment of Relapsed/Refractory CLL Patients With PI3Kδ Inhibitor and Anti-CD20 Antibody Rapidly Decreases Tumor Burden but Could Induce Resistance
- Tumor Cell Survival Factors and Angiogenesis in Chronic Lymphocytic Leukemia: How Hot Is the Link?
- Unveiling the potential of CLL-1: a promising target for AML therapy
- Value of Serum Interleukin-22 In Patients With Chronic Lymphocytic Leukemia And Its Relation to Disease Characteristics
- Advanced Therapeutic Strategies and Resistance Mechanisms in CLL
with Dr. Shankara Paneesha - Critical Role of Diagnostic Markers in Differentiating CLL from Other Hematological Malignancies
with Dr. Julio Delgado

Facebook
X
LinkedIn
Forward